San Diego C Nick Hardwick vs. New England NT Vince Wilfork
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Hardwick is quick, agile, tough and technically sound, but he gives up 30 pounds to 325-pound Wilfork, the consummate 3-4 nose tackle. For the Chargers to have success running the ball, it is essential they get Wilfork blocked, and that probably will take a double-team from Hardwick and one of San Diego's guards. If that happens, ILBs Tedy Bruschi and Junior Seau should be able to stay pretty clean in their pursuit in the run game.