Note: ESPN's Joe Lunardi assigned a team of Bracketologists to put together Insider's Tournament Tips, offering historical analysis of the bracket and in-depth breakdowns on all 68 tournament teams to help you make smart picks.
The Irish could reach the Final Four in the right draw, but I don't like their chances against Purdue's defensive intensity in a potential Sweet 16 encounter. Notre Dame needs open shots to win, and those are few and far between against the Boilers.
Plus, you can enlist the help of Insider's Bracket Predictor tool to aid your picks.
Once the action starts, follow all the games on your desktop with our discreet RealTime Scoreboard.
Take a look inside the data used by the selection committee in seeding the bracket: