The Louisville Cardinals have the horses and the perfect jockey in March maestro Rick Pitino to make a run at a second straight national championship. What has to go right for the Cardinals to win it all, and what potential issues could keep them from reaching a third straight Final Four?
ESPN Insider has your answers, as Joe Lunardi has enlisted a team of Bracketologists to compile advanced metrics, key scouting intel and best- and worst-case tournament scenarios for all 68 teams to help you make smart picks in your bracket. Plus, as Lunardi fills out his bracket, he'll give you his prediction on how each team will fare.
Best wins: Cincinnati, SMU (twice), UConn
Worst losses: Kentucky, Memphis (twice)