Each week we preview one matchup per game that is such a mismatch that it should make an impact on the game, either through its exploitation or by changing a team's plans to try to compensate.
Chiefs RB Priest Holmes vs. Seahawks' linebackers
For the Seahawks, this has been their biggest mismatch for almost the entire season. There are plenty of other things to discuss about the Seahawks, but how can we ignore the league's worst run defense versus last year's rushing and total yards from scrimmage leader? The Seahawks did get some good news for once this week when Anthony Simmons returned to the practice field. He has been out with a high-ankle sprain since the first week of the season and will only see action in about half the team's plays. Middle linebacker Orlando Huff, subbing for first-year starter Isiaih Kacyvenski, played well in his first start last week, but the Seahawks still allowed over 200 yards rushing to the Broncos. Not only will they be hard pressed to stop Holmes on the ground, but the Chiefs running back is also the team's leading receiver, catching 20 more passes than TE Tony Gonzalez.
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