As always, if you need a bit more specific advice, see whether your questions have been answered in recent chat sessions. Here's the wrap from my Wednesday chat session, and my colleagues will be chatting Thursday and Friday. Remember this week there's a Thursday game, and then most of the Week 16 games will be played on Saturday, with one game scheduled for Sunday night and another on Monday. Phew. So don't wait until Sunday morning to do lineups, or you'll miss it. Best of luck in Week 16 and beyond!
To see Eric's top 100 flex rankings for Week 16, you must be an ESPN Insider.