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Andy Murray stages comeback to advance

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Get out of the way, Murray!

Adrian Mannarino hits a blazing backhand that pegs Andy Murray right in the back during their second-round match at the US Open.

NEW YORK -- 2012 US Open champion Andy Murray had to win the final three steamy sets to beat unorthodox Frenchman Adrian Mannarino 5-7, 4-6, 6-1, 6-3, 6-1 and advance to the third round.

On a day when two more men retired from their matches -- pushing the four-day male total to 12, a Grand Slam record in the Open era -- Murray spent 3 hours, 17 minutes in the cauldron of Arthur Ashe Stadium.

In a challenging first-round match, Murray beat Aussie bad boy Nick Kyrgios with patience and relentless defense. In the second, Murray needed to master his emotions -- and what looked to be mild cramping -- to book a Saturday encounter with No. 30 seed Thomaz Bellucci.

Murray has not lost in the second round of the US Open since his first appearance in 2005. Three years later, he advanced to the final, falling to Roger Federer, who won his fifth straight title. Four years after that, Murray won his first and only championship at Flushing Meadows, beating Novak Djokovic in the final.

For the first two sets Thursday, though, it wasn't about Murray at all. Mannarino, who hits unusually flat shots, struck 30 winners against 15 unforced errors and broke Murray's formidable serve three times while saving 7 of 8 break opportunities.

But Murray came back, winning 18 of the match's final 23 games, to improve to 21-1 in the first two rounds of the tournament all-time.

In other results Thursday, fifth-seeded Stan Wawrinka, the reigning French Open champion, beat 19-year-old Chung Hyeon 7-6 (2), 7-6 (4), 7-6 (6), but the match took more than three hours.

Wawrinka had 26 aces and 62 winners but a whopping 66 unforced errors against Hyeon, a South Korean who is ranked 69th. Wawrinka will face Ruben Bemelmans in the third round.

John Isner also swept through to the third round, defeating Mikhail Youzhny 6-3, 6-4, 6-4, and Donald Young rallied to win again, this time from a set down to beat Aljaz Bedene after erasing a two-set deficit to knock off Gilles Simon in his opener Tuesday.

No. 21 Ivo Karlovic and No. 28 Jack Sock were the two seeded men to be eliminated Thursday.

The Associated Press contributed to this report.