Where No. 1 seeds face trouble 

March, 16, 2011
3/16/11
3:46
PM ET

Tre'Von Willis, Josh SelbyUS PresswireAccording to Giant Killers, a UNLV-Kansas matchup could be "a bruising" affair.
So far this week in Giant Killers, we have been taking deep looks at matchups that could yield big upsets in what we now call the first two rounds of the NCAA tournament (the field of 68 and the field of 64). But there are potential Killers lurking in the middle seeds, too, whom you need to know about to fully fill out your brackets. Today we ask: If all the 1-seeds get by their 16-seed opponents, how safe will they be against 8- or 9-seed Giant Killers?

Short answer: Not very.