The reigning champs stood at No. 3 in each of the previous CFP rankings this season, but a heartbreaking loss to Michigan State (which rose to No. 5 this week) sent the Buckeyes spiraling down to No. 8 this week.
A three-point win over a three-win Boston College team wasn't good enough in the committee's eyes for the Fighting Irish to stay in the top four as they settle in at No. 6 this week.
Another matchup that could lead to a CFP shakeup is the Bedlam game between Oklahoma and No. 11 Oklahoma State. The Cowboys tumbled five spots after losing to Big 12 rival Baylor for their first loss of the season. The victory pushed the Bears up from No. 10 to No. 7 in this week's poll. While Oklahoma State fell out of the top ten this week, a win over the arch rival Sooners could serve as a shot in the arm while dashing any hopes Oklahoma has of vying for a national title.
While the Big 12 is filled with CFP possibilities, the SEC is taking some hits. Florida at No. 12 is the second-highest ranked school from the conference behind No. 2 Alabama. There are only two other entries from the SEC in this week's rankings with in-state foes Ole Miss at No. 18 and Mississippi State at No. 21.
The ACC has back-to-back entries with Florida State moving up one spot to No. 13 and North Carolina Tar Heels climbing three notches to No. 14. The Tar Heels, winners of 10 straight, can make a huge statement in two weeks if they can knock off top-ranked Clemson at home in Chapel Hill.
Houston, which had been in the running with Navy as the best team from a Group of 5 conference, fell from No. 19 to completely out of the rankings after UConn dealt the Cougars their first defeat of the season.