Travin Dural caught a 32-yard touchdown pass from Anthony Jennings and Leonard Fournette added a short scoring run for the Tigers (6-2, 2-2 Southeastern Conference), who raced to a 27-3 halftime lead en route to becoming bowl eligible for a school-record 15th straight year.
The Wildcats (5-2, 2-2) came to LSU in the thick of the SEC East race, only to be handed their fourth lopsided loss in as many trips to Death Valley since 2000.
Kentucky also saw freshman running back Stanley "Boom" Williams, their all-purpose yards leader, knocked from the game on a helmet-to-helmet hit during a kickoff return.
Ole Miss heads to death valley Saturday night
12:00 PM ET UAB Arkansas 3:30 PM ET 1 Mississippi State Kentucky 4:00 PM ET Vanderbilt Missouri 7:15 PM ET 3 Ole Miss 24 LSU 7:30 PM ET South Carolina 5 Auburn 7:30 PM ET 4 Alabama Tennessee