Five storylines: Clemson at Florida State 

September, 20, 2012
9/20/12
8:55
AM ET
After three consecutive easy victories, Florida State faces what will likely be its biggest challenge of the regular season, when No. 10 Clemson comes to town. The Tigers have won six of the last nine meetings between the two teams, but FSU is the heavy favorite this time around. Here are the five biggest storylines heading into Saturday's showdown.

1. What will EJ Manuel do on the big stage?
The hype for this game isn't getting to the Florida State quarterback, Manuel insists, but after sitting out last year's loss to Clemson with an injured shoulder, he's eager to get a chance to make his mark. Clint Trickett threw for 336 yards and three touchdowns in his first career start last season, and Manuel might need to do better this year.
FSU Reclaims No. 2 In Power Rankings
Three top-15 programs climb four positions in the ESPN College Football Power Rankings, and Florida State flips places with Ole Miss. College football reporter Adam Rittenberg joins Cary Chow to break down notable movers.
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