STILLWATER, Okla. -- Baker Mayfield threw two touchdown passes and ran for another score and No. 5 Oklahoma beat No. 9 Oklahoma State 58-23 on Saturday night to take the Big 12 title and likely a spot in the College Football Playoff.
Mayfield was knocked out of the previous game with a concussion, but he was fearless against the Cowboys, rushing for 77 yards and a touchdown. The Sooners (11-1, 8-1 Big 12, No. 3 CFP) gained 524 yards, including 344 on the ground, to claim their third win over a ranked opponent in three weeks.
It was just the third time the rivals have met when both ranked in the Top 10.
Oklahoma rolled to a 44-20 halftime lead. The Sooners gained 359 yards on 36 plays before the break. Perine had touchdown runs of 68 and 25 yards, and Mixon added a 66-yard scoring run in the half.
Walsh started for Mason Rudolph, who limped at times during the loss to Baylor the previous week. He entered the game in the second quarter, played one possession and threw an interception that Thomas returned 32 yards for a touchdown to give Oklahoma a 34-10 lead.
Walsh threw his first interception of the season in the second quarter when Thomas stepped in front of a pass and returned it 36 yards to set up Austin Seibert's 40-yard field goal that made it 44-17. It was the second-highest point total for Oklahoma in any half of a Bedlam game, trailing just the 45 points the Sooners scored in the first half of the 1970 game.
Mayfield's 5-yard keeper in the third quarter put the Sooners up 51-23.
Early in the fourth quarter, Perine, just a sophomore, became the 10th Sooner to rush for at least 3,000 yards in a career.
Follow Cliff Brunt on Twitter (at)CliffBruntAP